2-亚氨基硫烷盐酸盐
- 产品编号：P301
- CAS：4781-83-3
- 产品描述：修饰蛋白质或载体材料上的伯胺基，产生巯基基团，该位点的氨基电荷特性不改变，对蛋白质的三维活性结构影响较小。
化学结构
分子式: C4H8ClNS
分子量: 137.63
CAS No.: 4781-83-3
MDL No.: MFCD00039013
产品描述
2-Iminothiolane Hydrochloride
Traut’s Reagent
2(3H)-Thiophenimine, dihydro-, hydrochloride
2-亚氨基硫杂环戊烷盐酸盐
2-亚氨基硫烷盐酸盐
性状
熔点:198-201℃
外观: 白色结晶
保存温度: 2~8 ℃
溶解性: 溶于水；甲醇；乙醇；DMSO，不溶于乙醚
产品参数
| Specification | Characteristic | Requirement/Method |
| Physical | Color/Appearance |
White crystalline
Powder (Visual) |
| Foreign Material |
No Visually
Detectable (Visual) |
|
| Melt point | 198-201℃ | |
| solubility H2O | ≥100mg/ml 25℃ | |
| Chemical | Identity |
Conforms to
Standard (NMR) 亚氨基硫烷盐酸盐的核磁分析 |
| Chloride | 98-108% | |
| Purity |
≥ 95% (HPLC 208nm) |
|
| moisture content | <0.1% |
使用事项
2-Iminothiolane Hydrochloride is commercially available in
GMP quality and is commonly used in the PEGylation of
therapeutic proteins. For the transformation of a primary amine
to a sulfhydryl group in drugs and therapeutic
proteins.
参考文献
[1] Rajeeva Singh, Lana Kats; Formation
of N-Substituted 2-Iminothiolanes When Amino Groups in
Proteins and Peptides Are Modified by 2-Iminothiolane;
Analytical Biochemistry; Volume 236, Issue 1, p114–125,
1996; 
[2] Michael J. McCall; Simplified
method for conjugating macrocyclic bifunctional chelating
agents to antibodies via 2-iminothiolane; Bioconjugate Chem.;
1990, 1 (3), p222–226;
