AM PEGA resin

Chemical structure

Solid phase peptide synthesis (SPPS) has been extensively developed in the synthesis of biomacromolecules. One key factor for the success of solid-phase methods relates to the options of polymeric support. PEGA resins consist of dimethyl acrylamide cross-linked with polyethylene glycol. These supports swell extensively in a wide range of solvents and are permeable to macromolecules up to 35 kD, making them ideal for the preparation of combinatorial libraries, affinity purification and on-resin enzyme assays. For applications of these resins in SPPS and SPOS 

  

  Fig1: Swelling properties of PEGMatrix, PEGA and other resins

              

Fig2: Optimazation of peptife synthesis(14aa) on 2-Chlorotrityl Chloride resin(a) and PEGA resins(b)

Key Specifications

Specification	Characteristic	Requirement/Method
Physical	Color/Appearance	Colorless transparent bead shaped particles (Visual)
	Particle Size	50~100; 100-200 mesh
Chemical	Copolymer Matrix	Dimethyl Acrylamide cross-linked with polyethylene glycol,
	Degree of Cross Linking	1%
	Active Group	-NH2 HAc
	Active Group Capacity	0.2~ 2.0mmol/g
	Storage Temperature	2~8 ℃
	Working Temperature	2~40 ℃