CM PEGMatrix resin

Product Numbers: P103
CAS: 0
Product description: Based on the positive effects of PEG on peptide purity, we development a totally PEG resin, as same as ChemMatrix®. The PEG length and matrix structure was selected to obtain a loading range of 0.5 to 1.0 mmol/g and therefore have a binding capacity comparable to polystyrene.

INTRODUCTION

Chemical structure

Solid phase peptide synthesis (SPPS) has been extensively developed in the synthesis of biomacromolecules. One key factor for the success of solid-phase methods relates to the options of polymeric support. PEGMatrix resins consist with cross-linked polyethylene glycol. These supports swell extensively in a wide range of solvents and are permeable to macromolecules up to 35 kD, making them ideal for the preparation of combinatorial libraries, affinity purification and on-resin enzyme assays. For applications of these resins in SPPS and SPOS

Compared with the early PEGA resin, PEGMatrix resin has the following characteristics:
1.Exceptional Chemical Stability
PEGMatrix resin is made exclusively from stable chemical bond, which is highly chemically stable in the whole process of synthesis and cleavage. and also be applied to microwave heating synthesis.
2.Better Physical Performance
PEGMatrix resin can be good swelling in a variety of solventsdoes, and less occurred adhesion. the conversion rate is more fully.
3.Reaction Selectivity Increased
The PEG chain in the PEGMatrix resin provides a sufficient condition for the polypeptide reaction, which provides a direct synthesis of the long peptides and complex special peptides.

Fig1: Swelling properties of PEGMatrix, PEGA and other resins

Fig2: Optimazation of peptide synthesis on Wang resins(a) and PEGMatrix resins(f)

Key Specifications

Specification	Characteristic	Requirement/Method
Physical	Color/Appearance	Colorless transparent bead shaped particles (Visual)
Physical	Particle Size	50~100 mesh
Chemical	Copolymer Matrix	Acrylic cross-linked with polyethylene glycol,
	Active Group	-COOH
	Active Group Capacity	0.2-1.0mmol/g
	Storage Temperature	2~8 ℃
	Working Temperature	2~40 ℃

Ref

[1] Review of ChemMatrix(®) resin on sigmaaldrich

[2] ChemMatrix(®) resin for complex peptides and combinatorial chemistry

[3] Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

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