2-Iminothiolane
- Product Numbers: P301
- CAS: 4781-83-3
- Product description: 2-Iminothiolane Hydrochloride, Traut's Reagent 2(3H)-Thiophenimine, dihydro-, hydrochloride
Chemical structure
Formula: C4H8ClNS
Mw:ca.: 137.63
CAS No.: 4781-83-3
MDL No.: MFCD00039013
Product identification
2-Iminothiolane Hydrochloride
Traut’s Reagent
2(3H)-Thiophenimine, dihydro-, hydrochloride
2-亚氨基硫杂环戊烷盐酸盐
2-亚氨基硫烷盐酸盐
Physical properties
Melting point :198-201℃
Appearance: White crystalline powder
Storage Temperature: 2~8 ℃
Solubility: soluble in water, methanol, ethanol, DMSO;
insoluble in ether
Key Specifications
| Specification | Characteristic | Requirement/Method |
| Physical | Color/Appearance |
White crystalline
Powder (Visual) |
| Foreign Material |
No Visually
Detectable (Visual) |
|
| Melt point | 198-201℃ | |
| solubility H2O | ≥100mg/ml 25℃ | |
| Chemical | Identity |
Conforms to
Standard (NMR) |
| Chloride | 98-108% | |
| Purity |
≥ 95% (HPLC 208nm) |
|
| moisture content | <0.1% |
Uses
2-Iminothiolane Hydrochloride is commercially available in
GMP quality and is commonly used in the PEGylation of
therapeutic proteins. For the transformation of a primary amine
to a sulfhydryl group in drugs and therapeutic
proteins.
Ref:
[1] Rajeeva Singh, Lana Kats; Formation
of N-Substituted 2-Iminothiolanes When Amino Groups in
Proteins and Peptides Are Modified by 2-Iminothiolane;
Analytical Biochemistry; Volume 236, Issue 1, p114–125,
1996; 
[2] Michael J. McCall; Simplified
method for conjugating macrocyclic bifunctional chelating
agents to antibodies via 2-iminothiolane; Bioconjugate Chem.;
1990, 1 (3), p222–226;
